New Madrid County Vacations & Trips from $557
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County
Sikeston
New Madrid
The Latest New Madrid County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Drury Inn & Suites Cape Girardeau
Price was $609, price is now $589 per person
$589
per person
Apr 23 - Apr 25
found 8 hours ago
Roundtrip non-stop flight included
Orlando (ORL) to Cape Girardeau (CGI)
9.4/10 Exceptional! (1,005 reviews)
Easy parking. Very clean room. Accommodating. Nice and helpful staff.
Reviewed on Mar 11, 2026
Drury Inn & Suites Jackson MO
Price was $591, price is now $574 per person
$574
per person
Apr 23 - Apr 25
found 8 hours ago
Roundtrip non-stop flight included
Orlando (ORL) to Cape Girardeau (CGI)
9.6/10 Exceptional! (1,006 reviews)
Stayed there for 10 years when we leave the Gulf to head home. Great place to stop. Meals for supper and breakfast.
Reviewed on Mar 4, 2026
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $108 total per night from Mar 22 to Mar 23
$108 total
Mar 22 - Mar 23
Total with taxes and fees
9/10 Wonderful! (498 reviews)
East, friendly check in. Beautiful, large room.
Reviewed on Mar 9, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$93 nightly
The price is $105 total per night from Mar 22 to Mar 23
$105 total
Mar 22 - Mar 23
Total with taxes and fees
8.6/10 Excellent! (449 reviews)
Nice room
Reviewed on Mar 5, 2026
New Orleans Inn Portageville
600 US-61 Portageville MO
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $60 total per night from Mar 15 to Mar 16
$60 total
Mar 15 - Mar 16
Total with taxes and fees
8/10 Very Good! (748 reviews)
Room was comfortable
Reviewed on Mar 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
