Name: Holiday Inn Express & Suites Sikeston Southwest by IHG
Price range: $121 total
Rating: 8.6

Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

Top destinations in New Madrid County

A tree with sunlight filtering through its leaves, creating a warm glow.

Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

The Latest New Madrid County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Holiday Inn Poplar Bluff by IHG

$522

per person

Aug 22 - Aug 25

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Cape Girardeau (CGI)

8.8/10 Excellent! (746 reviews)

Staff was very friendly and helpful. There is an attached restaurant serving breakfast and dinner. The hotel, although clean, is a bit dated. Rooms, as well as the hotel overall could use a face lift.

Reviewed on Jun 21, 2026

Drury Inn & Suites Jackson MO

$541

per person

Aug 22 - Aug 25

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Cape Girardeau (CGI)

9.6/10 Exceptional! (1,016 reviews)

Clean rooms, pool, dining. Love the evening happy hour and the morning breakfast too!

Reviewed on Jun 21, 2026

Find the Best New Madrid County Vacation Packages

New Madrid County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Population	3,000

New Madrid County Hotel Deals

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$105 nightly

$118 total

Jul 19 - Jul 20

Total with taxes and fees

9/10 Wonderful! (579 reviews)

"Hampton are always comfortable…you know what to expect…friendly, clean and well maintained"

Reviewed on Jun 22, 2026

Fairfield Inn & Suites by Marriott Sikeston

1239 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$110 nightly

$125 total

Jul 2 - Jul 3

Total with taxes and fees

9.4/10 Exceptional! (93 reviews)

"Everything was good. Rooms were cleaned, breakfast was good and fresh, and staff was helpful and nice.."

Reviewed on Jun 16, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Fully refundable

$107 nightly

$121 total

Jun 28 - Jun 29

Total with taxes and fees

8.6/10 Excellent! (470 reviews)

"Comfortable beds, good breakfast!"

Reviewed on Jun 22, 2026

See all 102 properties in New Madrid County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.