Name: Holiday Inn Express & Suites Sikeston Southwest by IHG
Price range: $114 total
Rating: 8.6

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your New Madrid County Vacation

With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.

Top destinations in New Madrid County

Good Day Sunshine Early Morning Sunshine passes through the fog and scatters through the leaves of a tree in Scott County Missouri

Mississippi River Walk at New Madrid. A magnificent view of the Mississippi river from atop of the levee. A steamboat is docked down river. .

Find the Best New Madrid County Vacation Packages

New Madrid County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Population	3,000

New Madrid County Hotel Deals

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$102 nightly

$115 total

May 17 - May 18

Total with taxes and fees

9/10 Wonderful! (555 reviews)

Clean Friendly staff Quiet Convenient

Reviewed on May 5, 2026

Fairfield Inn & Suites by Marriott Sikeston

1239 Commerce Drive Sikeston MO

Fully refundableReserve now, pay when you stay

$110 nightly

$124 total

May 17 - May 18

Total with taxes and fees

9.4/10 Exceptional! (74 reviews)

Clean, comfortable room. Friendly staff

Reviewed on May 1, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

Fully refundable

$101 nightly

$114 total

Jun 7 - Jun 8

Total with taxes and fees

8.6/10 Excellent! (462 reviews)

The staff was friendly and helpful even when arriving late in the evening. Room was clean and bed was very comfortable.

Reviewed on May 1, 2026

See all 99 properties in New Madrid County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.