
New Madrid County Vacations & Trips
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County

Sikeston

New Madrid
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals

Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$102 nightly
The price is $115 total per night from May 17 to May 18
$115 total
May 17 - May 18
Total with taxes and fees
9/10 Wonderful! (555 reviews)
Clean Friendly staff Quiet Convenient
Reviewed on May 5, 2026

Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $124 total per night from May 17 to May 18
$124 total
May 17 - May 18
Total with taxes and fees
9.4/10 Exceptional! (74 reviews)
Clean, comfortable room. Friendly staff
Reviewed on May 1, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$101 nightly
The price is $114 total per night from Jun 7 to Jun 8
$114 total
Jun 7 - Jun 8
Total with taxes and fees
8.6/10 Excellent! (462 reviews)
The staff was friendly and helpful even when arriving late in the evening. Room was clean and bed was very comfortable.
Reviewed on May 1, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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