New Madrid County Vacations & Trips from $641
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County
Sikeston
New Madrid
The Latest New Madrid County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel
$641
per person
Sep 18 - Sep 20
found 1 day ago
Roundtrip non-stop flight included
Denver (DEN) to Cape Girardeau (CGI)
9.4/10 Exceptional! (105 reviews)
I loved how cute and well decorated everything was, from the room to the lobby area. Next time when we have more time, I hope to use the restaurant, shop, and ice cream! So yes, we will be back!
Reviewed on Aug 18, 2026
Makanda Inn
$1,221
per person
Oct 22 - Oct 25
found 1 day ago
Roundtrip flight included
Gainesville (GNV) to Cape Girardeau (CGI)
10/10 Exceptional! (39 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.
Reviewed on Jul 22, 2026
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
$97 nightly
$110 total
Aug 23 - Aug 24
Total with taxes and fees
8.8/10 Excellent! (499 reviews)
"Everything was good. Just a bit pricey compared to competition in my opinion."
Reviewed on Aug 16, 2026
Hampton Inn Sikeston
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$98 nightly
$110 total
Aug 27 - Aug 28
Total with taxes and fees
9/10 Wonderful! (609 reviews)
"Room was as described and the breakfast was great and room nice and cool"
Reviewed on Aug 16, 2026
Fairfield Inn & Suites by Marriott Sikeston
1239 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
$109 nightly
$123 total
Aug 23 - Aug 24
Total with taxes and fees
9.4/10 Exceptional! (103 reviews)
"Staff were excellent! Very personable with us!"
Reviewed on Aug 12, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular New Madrid County attractions
Hunter-Dawson State Historic Site
7.6/10 (13 reviews)
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
New Madrid Historical Museum
8.2/10 (36 reviews)
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
River Ridge Winery
8.4/10 (15 reviews)
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
Marston Community Center
Marston Community Center is just one of the places to see in Marston, so why not enjoy the other things to explore during your travels? Amble around the area's parks or experience its museums.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.