New Madrid County Vacations & Trips from $860
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Your New Madrid County Vacation
With a New Madrid County vacation package, you can forget about planning hassles and focus on experiencing all this wonderful destination has on offer. During your trip to New Madrid County, you'll want to tick off a few of its most famous cities. What can't you miss? Portageville. Stop dreaming and start packing, because your New Madrid County vacation is only a few clicks away with Expedia.
Top destinations in New Madrid County
Sikeston
The Latest New Madrid County Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Town House Inn
per person
Sep 1 - Sep 9
found 12 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cape Girardeau (CGI)
7.8/10 Good! (396 reviews)
The property Manager, Mr. Champ very hospitable, & personally walks & survey the property & surroundings, this was my second stay here & I will definitely be visiting again soon, highly recommend!!!
Reviewed on Jul 21, 2025
Hampton Inn Carbondale
per person
Sep 1 - Sep 9
found 12 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Cape Girardeau (CGI)
8.4/10 Very Good! (569 reviews)
The bed was comfortable, there was a choice of pillows. The bathroom was clean. It did lack a hairdryer (which I reported to the front desk upon checkout. The breakfast was outstanding! I complimented the cook.
Reviewed on Jun 7, 2025
Find the Best New Madrid County Vacation Packages
New Madrid County Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Population | 3,000 |
New Madrid County Hotel Deals
Hampton Inn Sikeston
1240 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
$108 nightly
The price is $122 total per night from Aug 23 to Aug 24
$122 total
Aug 23 - Aug 24
Total includes taxes and fees
8.8/10 Excellent! (368 reviews)
"It was great"
Reviewed on Jul 27, 2025
Fairfield by Marriott Inn & Suites Sikeston
1239 Commerce Drive, Sikeston, MO
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $129 total per night from Aug 10 to Aug 11
$129 total
Aug 10 - Aug 11
Total includes taxes and fees
9.8/10 Exceptional! (16 reviews)
"Absolutely excellent. Brand new hotel. Spotless. Staff were friendly and welcoming."
Reviewed on Jul 26, 2025
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr, Sikeston, MO
Fully refundable
$128 nightly
The price is $145 total per night from Aug 17 to Aug 18
$145 total
Aug 17 - Aug 18
Total includes taxes and fees
8.6/10 Excellent! (417 reviews)
"It would be nice if the hotel would release my room deposit..i hate it when its held by a hotel for longer than a couple of days, they"
Reviewed on Jul 25, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.